| G1 Therapeutics, Inc. (GTHX) | 2.88% | $376.17M | -60.97% | 95.57% | 1.84 |
| DiaMedica Therapeutics, Inc. (DMAC) | 1.87% | $172.27M | N/A | N/A | N/A |
| Axogen, Inc. (AXGN) | 1.86% | $570.66M | 25.57% | 73.77% | 2.07 |
| Aldeyra Therapeutics, Inc. (ALDX) | 1.76% | $364.25M | N/A | N/A | N/A |
| Exagen, Inc. (XGN) | 1.60% | $54.59M | 6.56% | 60.12% | 0.57 |
| MediciNova, Inc. (MNOV) | 1.51% | $103.00M | N/A | N/A | 26.78 |
| Akebia Therapeutics, Inc. (AKBA) | 1.48% | $283.89M | -22.58% | 60.03% | 1.60 |
| Leap Therapeutics, Inc. (LPTX) | 1.46% | $107.52M | N/A | N/A | N/A |
| Rigel Pharmaceuticals, Inc. (RIGL) | 1.40% | $234.37M | 37.03% | 92.38% | 1.19 |
| Accelerate Diagnostics, Inc. (AXDX) | 1.35% | $40.97M | 2.23% | 22.64% | 4.88 |
| Ocular Therapeutix, Inc. (OCUL) | 1.34% | $1.31B | 8.26% | 90.82% | 12.27 |
| Annovis Bio, Inc. (ANVS) | 1.33% | $102.74M | N/A | N/A | N/A |
| CorMedix, Inc. (CRMD) | 1.31% | $321.75M | N/A | 36.75% | 253.66 |
| Sutro Biopharma, Inc. (STRO) | 1.28% | $337.69M | 146.89% | 93.04% | 0.01 |
| IGM Biosciences, Inc. (IGMS) | 1.28% | $315.90M | 179.91% | -81.50% | 67.98 |
| Anixa Biosciences, Inc. (ANIX) | 1.27% | $102.74M | N/A | N/A | N/A |
| XBiotech, Inc. (XBIT) | 1.26% | $198.62M | N/A | N/A | N/A |
| aTyr Pharma, Inc. (LIFE) | 1.26% | $142.50M | N/A | N/A | 81.55 |
| Solid Biosciences, Inc. (SLDB) | 1.26% | $313.01M | N/A | N/A | N/A |
| Abeona Therapeutics, Inc. (ABEO) | 1.21% | $240.39M | -100.00% | N/A | N/A |
| Immunic, Inc. (IMUX) | 1.21% | $120.71M | N/A | N/A | N/A |
| Delcath Systems, Inc. (DCTH) | 1.20% | $270.76M | 1,468.89% | 80.44% | 18.78 |
| Astria Therapeutics, Inc. (ATXS) | 1.18% | $627.45M | N/A | N/A | N/A |
| CARA Therapeutics, Inc. (CARA) | 1.16% | $17.67M | -85.71% | 92.23% | 0.42 |
| SIGA Technologies, Inc. (SIGA) | 1.16% | $550.26M | 271.05% | 43.55% | 2.54 |
| Annexon, Inc. (ANNX) | 1.15% | $607.51M | N/A | N/A | N/A |
| Atara Biotherapeutics, Inc. (ATRA) | 1.15% | $53.73M | 2,892.69% | 83.84% | 1.71 |
| Neoleukin Therapeutics, Inc. (NLTX) | 1.13% | $454.62M | N/A | 11.68% | 515.01 |
| InspireMD, Inc. (NSPR) | 1.11% | $71.98M | 5.46% | 19.03% | 6.65 |
| PDS Biotechnology Corp. (PDSB) | 1.11% | $107.88M | N/A | N/A | N/A |
| ESSA Pharma, Inc. (EPIX) | 1.10% | $238.71M | N/A | N/A | N/A |
| Trevi Therapeutics, Inc. (TRVI) | 1.09% | $214.15M | N/A | N/A | N/A |
| Assembly Biosciences, Inc. (ASMB) | 1.09% | $107.81M | N/A | 99.62% | -1.40 |
| ProQR Therapeutics NV (PRQR) | 1.08% | $151.52M | 417.56% | 88.72% | 3.09 |
| Aadi Bioscience, Inc. (AADI) | 1.08% | $45.05M | -0.37% | 87.41% | -1.36 |
| NeuroPace, Inc. (NPCE) | 1.08% | $210.22M | 16.63% | 73.40% | 3.29 |
| Precision BioSciences, Inc. (DTIL) | 1.06% | $71.90M | 152.15% | 97.23% | -0.28 |
| CollPlant Biotechnologies Ltd. (CLGN) | 1.06% | $58.65M | -97.55% | -220.08% | 59.74 |
| Galectin Therapeutics, Inc. (GALT) | 1.05% | $153.20M | N/A | N/A | N/A |
| KalVista Pharmaceuticals, Inc. (KALV) | 1.05% | $531.63M | N/A | N/A | N/A |
| Atea Pharmaceuticals, Inc. (AVIR) | 1.05% | $303.92M | N/A | N/A | N/A |
| VYNE Therapeutics, Inc. (VYNE) | 1.04% | $28.02M | 46.67% | N/A | 12.12 |
| AlloVir, Inc. (ALVR) | 1.03% | $86.66M | N/A | N/A | N/A |
| Oramed Pharmaceuticals, Inc. (ORMP) | 1.02% | $95.81M | -100.00% | N/A | N/A |
| Kineta, Inc. (YMTX) | 1.02% | $8.08M | -100.00% | N/A | N/A |
| ADC Therapeutics SA (ADCT) | 1.02% | $260.95M | -9.71% | 88.20% | 1.90 |
| Lyra Therapeutics, Inc. (LYRA) | 1.01% | $17.85M | 30.57% | 75.75% | -6.94 |
| Adverum Biotechnologies, Inc. (ADVM) | 1.00% | $140.61M | N/A | N/A | N/A |
| Larimar Therapeutics, Inc. (LRMR) | 0.99% | $513.64M | N/A | N/A | N/A |
| InflaRx NV (IFRX) | 0.99% | $89.50M | N/A | -5,376.69% | 202.13 |
| Cidara Therapeutics, Inc. (CDTX) | 0.98% | $80.52M | -96.03% | 81.13% | -2.70 |
| Chimerix, Inc. (CMRX) | 0.98% | $78.52M | 396.15% | 81.40% | -473.23 |
| Carisma Therapeutics, Inc. (SESN) | 0.98% | $41.54M | 158.34% | 97.23% | 1.28 |
| SELLAS Life Sciences Group, Inc. (SLS) | 0.98% | $76.56M | N/A | N/A | N/A |
| VistaGen Therapeutics, Inc. (VTGN) | 0.97% | $87.93M | -52.70% | -79.76% | 0.13 |
| Nektar Therapeutics (NKTR) | 0.97% | $206.17M | 14.59% | 58.53% | 2.23 |
| Acumen Pharmaceuticals, Inc. (ABOS) | 0.96% | $133.38M | N/A | N/A | N/A |
| Spero Therapeutics, Inc. (SPRO) | 0.96% | $71.07M | 663.58% | 99.97% | 0.11 |
| electroCore, Inc. (ECOR) | 0.95% | $38.29M | 72.88% | 86.35% | 1.64 |
| IRIDEX Corp. (IRIX) | 0.94% | $33.02M | -1.74% | 40.00% | 0.67 |
| Vivani Medical, Inc. (EYES) | 0.94% | $64.65M | N/A | N/A | N/A |
| Enlivex Therapeutics Ltd. (ENLV) | 0.93% | $26.51M | N/A | N/A | N/A |
| CytomX Therapeutics, Inc. (CTMX) | 0.93% | $93.74M | 1.58% | 98.17% | -0.18 |
| PMV Pharmaceuticals, Inc. (PMVP) | 0.93% | $77.28M | N/A | N/A | N/A |
| Galecto, Inc. (GLTO) | 0.90% | $12.11M | N/A | N/A | N/A |
| Kodiak Sciences, Inc. (KOD) | 0.88% | $121.54M | N/A | N/A | N/A |
| Lexicon Pharmaceuticals, Inc. (LXRX) | 0.87% | $582.00M | 419.56% | 81.48% | 87.32 |
| Cardiff Oncology, Inc. (CRDF) | 0.86% | $98.22M | 50.93% | 35.58% | 61.71 |
| Ocugen, Inc. (OCGN) | 0.86% | $328.16M | N/A | 49.34% | 109.45 |
| Achieve Life Sciences, Inc. (ACHV) | 0.84% | $143.03M | N/A | N/A | N/A |
| Immuneering Corp. (IMRX) | 0.83% | $34.99M | N/A | N/A | N/A |
| Vanda Pharmaceuticals, Inc. (VNDA) | 0.82% | $292.61M | 9.59% | 91.11% | -0.28 |
| Sol-Gel Technologies Ltd. (SLGL) | 0.82% | $18.94M | 814.65% | N/A | -0.65 |
| Mind Medicine (MindMed), Inc. (MNMD) | 0.81% | $483.69M | N/A | N/A | N/A |
| SOPHiA GENETICS SA (SOPH) | 0.79% | $245.16M | 5.01% | 68.17% | 3.49 |
| Relmada Therapeutics, Inc. (RLMD) | 0.79% | $72.42M | N/A | N/A | N/A |
| Inovio Pharmaceuticals, Inc. (INO) | 0.78% | $163.06M | -55.41% | -722.36% | 206.67 |
| Ocuphire Pharma, Inc. (OCUP) | 0.76% | $31.44M | -69.73% | N/A | -0.12 |
| Verastem, Inc. (VSTM) | 0.76% | $96.58M | N/A | 99.94% | 5.97 |
| Minerva Neurosciences, Inc. (NERV) | 0.76% | $18.25M | N/A | N/A | N/A |
| Voyager Therapeutics, Inc. (VYGR) | 0.76% | $334.29M | 509.48% | 95.29% | 0.92 |
| Karyopharm Therapeutics, Inc. (KPTI) | 0.75% | $91.04M | 13.86% | 96.36% | 1.22 |
| Esperion Therapeutics, Inc. (ESPR) | 0.75% | $323.77M | 186.33% | 78.85% | 2.83 |
| ReWalk Robotics Ltd. (RWLK) | 0.75% | $27.11M | 401.65% | 33.65% | 0.89 |
| AC Immune SA (ACIU) | 0.74% | $298.04M | N/A | N/A | 11.81 |
| Cellectar Biosciences, Inc. (CLRB) | 0.73% | $74.57M | N/A | N/A | N/A |
| Daré Bioscience, Inc. (DARE) | 0.66% | $29.23M | N/A | 31.20% | 8.31 |
| SCYNEXIS, Inc. (SCYX) | 0.65% | $48.08M | -99.44% | N/A | 4.05 |
| Mersana Therapeutics, Inc. (MRSN) | 0.63% | $165.61M | -78.48% | 82.42% | 3.86 |
| Curis, Inc. (CRIS) | 0.63% | $29.78M | 15.89% | 97.09% | 5.29 |
| Tempest Therapeutics, Inc. (TPST) | 0.61% | $31.26M | N/A | N/A | N/A |
| GlycoMimetics, Inc. (GLYC) | 0.61% | $10.13M | N/A | N/A | -377.86 |
| Precigen, Inc. (PGEN) | 0.61% | $270.77M | -59.42% | -209.90% | 87.84 |
| Allakos, Inc. (ALLK) | 0.57% | $56.49M | N/A | N/A | N/A |
| BioVie, Inc. (BIVI) | 0.53% | $15.23M | N/A | N/A | N/A |
| Cognition Therapeutics, Inc. (CGTX) | 0.30% | $22.87M | N/A | N/A | N/A |
| Syros Pharmaceuticals, Inc. (SYRS) | 0.27% | $40.49M | -100.00% | N/A | 44.44 |
| Verrica Pharmaceuticals, Inc. (VRCA) | 0.26% | $81.50M | 2,744.51% | 89.53% | 25.41 |
| Actinium Pharmaceuticals, Inc. (ATNM) | 0.24% | $55.45M | N/A | N/A | 1,710.80 |