Index Performance
Overview
Description
The pharmaceutical industry, particularly companies developing treatments for high lipoprotein(a) (Lp(a)), offers significant growth potential due to the increasing recognition of Lp(a) as a critical risk factor for cardiovascular diseases. Lp(a) is a genetic variant of LDL cholesterol that has been difficult to treat with conventional statins. Recent advancements in biotechnology and gene editing are driving the development of novel therapies specifically targeting Lp(a). The aging global population and rising awareness of preventive cardiovascular health also bolster demand. Additionally, regulatory support and lucrative market opportunities are incentivizing pharmaceutical companies to invest in research and development of innovative Lp(a)-lowering drugs. - [[Gene Editing Therapies]]: Focus on companies using CRISPR/Cas9 and other gene editing technologies to address genetic causes of high Lp(a). - [[mRNA-based Treatments]]: Investment in firms developing mRNA technology for targeted therapies aimed at reducing Lp(a) levels. - [[Apolipoprotein(a) Inhibitors]]: Companies involved in research and production of drugs that specifically inhibit the synthesis of apolipoprotein(a), a key component of Lp(a). - [[RNA Interference (RNAi) Drugs]]: Firms leveraging RNAi technology to silence genes responsible for the overproduction of lipoprotein(a). - [[Biologics and Monoclonal Antibodies]]: Investing in companies that are creating biologics or monoclonal antibodies to neutralize Lp(a) in the bloodstream. This index was generated with help from Thematic Analyst.
- Inception Date07/25/2024
- WeightingEqual
- # of holdings8
What's inside?
Holdings
All holdings as of September 6, 2024
Eli Lilly & Co. (LLY) | 16.28% | $857.96B | 35.98% | 80.80% | 21.69 |
Ionis Pharmaceuticals, Inc. (IONS) | 13.39% | $6.86B | 19.55% | 95.67% | 8.42 |
Silence Therapeutics Plc (SLN) | 13.14% | $870.21M | -93.38% | -341.14% | 30.89 |
Arcturus Therapeutics Holdings, Inc. (ARCT) | 12.04% | $505.42M | 380.67% | 98.04% | 2.48 |
CRISPR Therapeutics AG (CRSP) | 11.48% | $3.80B | -99.26% | -10,920.50% | 13.93 |
Arrowhead Pharmaceuticals, Inc. (ARWR) | 11.37% | $2.76B | -100.00% | N/A | 165.61 |
Amarin Corp. Plc (AMRN) | 11.24% | $246.91M | -15.99% | 62.24% | -0.06 |
Verve Therapeutics, Inc. (VERV) | 11.08% | $473.47M | 219.73% | 75.09% | -4.48 |